Use the drop-down menus below to match the scientist(s) to their contribution to the discovery of base pairings. studied the role of rna in protein synthesis, specifically in the bacteria e. coli. created an accurate model of the structure of dna. proposed the polynucleic model, stating that dna and rna were composed of nucleotides. concluded that, in dna, adenine levels were equal to thymine levels and cytosine levels were equal to guanine levels.
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1-Nirenberg and Matthaei
2-Watson and Crick
Polynucleic model of DNA and RNA was proposed by Phoebus Aaron Levene in 1909.
In early 1900's, Phoebus Aaron Levene worked on the composition of nucleic acid and after analysis found that DNA molecule was made of smaller molecules called nucleotides made of pentose sugar (deoxyribose), phosphates (PO⁴) and nitrogenous bases (adenine, thymine, guanine and cytosine) and called them backbone of the DNA.
Levene also showed the linked order of nucleotides -phosphate-sugar-base to form units as well as the differences between the pentose sugar of DNA and RNA.
The following are the scientists known to their contribution to the discovery of base pairingsWhile the scientific community is still uncertain who to credit for the known role of RNA for protein synthesis (or the mRNA function), among the frontrunners were Arthur Pardee, Francois Jacob and Jacques Monod (PaJaMo).Phoebus Levene proposed the “polynucleotide model” where he stated that the DNA must be a chain of nucleotides, each of which contains one of the four nitrogenous bases (A, T, G and C).Based on Rosalind Franklin’s X-ray crystallography results and previous other studies, James Watson and Francis Crick made an accurate model of the structure of DNA. They only used cardboard cutouts, wires and clamps to create the DNA double-helix model, which won them the Nobel Prize in Physiology or Medicine (along with Maurice Wilkins) in 1962.Erwin Chargaff observed that the adenine and thymine levels as well as cytosine and guanine levels are equal. Thus, the amount of purines and pyrimidines are always equal. This has now been named the “Chargaff’s rule.”